By G. V. Sherbet (auth.)

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Its presence or absence in the connective tissue stroma bore no relationship to the progression of the disease, including the metastatic behaviour of the tumour. In some of these studies, the procedures involved in the isolation of cells from the primary and metastatic tumours and the tissue culture environment may have altered the picture. Nonetheless, these investigations represent a worthy beginning, which have encouraged other approaches to the problem. In adenocarcinoma of the rectum, fibronectin is found in the connective tissue stroma.

The extracellular matrix is composed of collagens, proteoglycans, elastin, hyaluronic acid and glycoproteins. The interaction occurring between cells and this extracellular matrix is believed to be an important event in a variety of biological processes such as embryonic development and pattern formation, neoplasia, and cellular motility, whether occurring in the context of embryonic development or in the invasive processes associated with cancer. Glycoprotein components of the matrix such as fibronectin and laminin are also associated with the cell surface and often make up a significant proportion of membrane glycoprotein.

G. fibronectin, and this deletion was prevented by antiproteinases such as aprotinin and leupeptin. Indeed, gliomas behaved in a similar manner to high-metastasis variants of B16 murine melanomas (seep. 43). There are several factors which ought to be taken into account in studies on PA activity, especially in relation to the metastatic process. One is the modulation of PA activity by the hormonal environment of the tumour bearer. Mira-y-Lopez et al. (1983) have reported that the pattern of PA response and hormonal parameters are significantly related and that P A production was inhibited by hydrocortisone in three tumour models studied, of which two had been induced by carcinogens and a third was a virally induced tumour.

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The Metastatic Spread of Cancer: Reflections upon its by G. V. Sherbet (auth.)
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