By Krishna Vaddi, Margaret Keller and Robert C. Newton (Auth.)

How do you retain song of simple info at the proteins you're employed with? the place do you discover info in their physicochemical houses, amino acid sequences, gene association? Are you bored with scanning evaluate articles, fundamental papers and databases to find that elusive truth?
The educational Press FactsBook sequence will fulfill scientists and medical researchers struggling with details overload. every one quantity offers a catalog of the fundamental homes of households of molecules. Gene association, amino acid sequences, physicochemical homes, and organic job are offered utilizing a typical, easy-to-follow layout. Taken jointly they assemble every little thing you need to learn about proteins yet are too busy to appear for. The Chemokine FactsBook comprises greater than forty entries on chemokines, and chemokine receptors from human or different starting place, together with IL-8, MCP-1, C5-a, RANTES, Lymphotactin, and CC CKR-1.
The textual content presents details on tissue resources, aim cells, physicochemical homes, transcription components, rules of expression in sickness, receptor-binding features, gene constitution and site, amino acid sequences, and accession numbers and references.

Key Features
* comprises over forty entries on chemokines and chemokine receptors from human or different beginning, including:
* IL-8
* MCP-1
* C5-a
* Lymphotactin
* CC CKR-1
Entries offer info on:
* Tissue sources
* goal cells
* Physicochemical properties
* Transcription factors
* law of expression
* Expression in disease
* Receptor-binding characteristics
* Gene constitution and location
* Amino acid sequences
* Database accession numbers
* References

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1991) /. Biol. Chem. 266, 23128-23134. Matsushima, K. et al. (1988) /. Exp. Med. 167, 1883-1893. Ishikawa, J. et al. (1993) Gene 131, 305-306. Lin, G. et al. (1994) /. Biol. Chem. 269, 77-85. Yoshimura, T. and Yukhi, N. (1991) /. Immunol. 146, 3483-3488. Legastelois, I. et al. (1994) Gene 150, 367-369. MGSA Melanoma growth stimulatory activity Alternative names GRO-a, neutrophil activating protein 3 (NAP-3), KC (murine), N51 (murine), cytokine-induced neutrophil chemoattractant (CINC) (rat), rabbit permeability factor 2 (RPF-2) Family a family (CXC family) Molecule MGSA was originally found as a mitogenic polypeptide secreted by human melanoma cells.

3 M NaCl is required to dissociate the proteoglycan PF4 complex"'. 6 1-31 1-29 ? a. 8) Molecular weight 10845 11286 9129 9644 Transcription factors Transient expression experiments with rat bone marrow cells and other cell lines reveal a complex interplay between a core promoter domain from - 9 7 to the transcriptional start site and an enhancer/silencer domain from -448 to -112. The core promoter contains a GATA site at - 3 1 to -28 whose mutation to TATA or AATA decreases tissue specificity and moderately affects expression in megakaryocytes as well as a positively acting subdomain from Platelet factor 4 - 9 7 to - 8 3 whose removal decreases overall transcription v^ithout affecting tissue specificity.

268, 541-546. Schraw, W. and Richmond, A. (1995) Biochemistry 34, 13760-13767. Moser, B. et al. (1991) /. Biol Chem. 266, 10666-10671. Balentien, E. et al. (1990) Biochemistry 29, 10225-10233. S. et al. (1994) /. Biol Chem. 269, 32909-32915. E. et al. (1990) Nucleic Acids Res. 18, 6543-6456. Oquendo, R et al. (1989) /. Biol Chem. 264, 4133-4137. Anisowicz, A. et al. (1987) Proc. Natl Acad. Scl USA 84, 7188-7192. C. et al. (1994) Gene 151, 337-338. Konishi, K. et al. (1993) Gene 126, 285-286. -TG^ and secreted from platelets following stimulation and aggregation.

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The Chemokine Facts: Book by Krishna Vaddi, Margaret Keller and Robert C. Newton (Auth.)
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