By F. A. O. Mendelsohn
This paintings surveys the distribution of neuro-transmitter receptors within the human mind and spinal wire. It gains two hundred pictures of autoradiograms demonstrating the distribution of receptor subtypes for the classical monoamine transmitters, the excitatory and inhibitory amino acids, and others, in addition to discussing codistribution and attainable interactions between receptors. The ebook positive factors facts at the distribution of neuro-transmitter receptors within the human mind and spinal twine and diverse pictures of radio-labelled receptor populations
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Extra info for Receptors in the Human Nervous System
Neurosci. 8, 493-501. B. (1984). Voltage-dependent block by Mg + 2 of NMDA responses in spinal cord neurones. Nature 309, 261-263. G. (1989). Location, structure, and sites of synthesis of the GABAA receptor in the central nervous system. In E A Barnard and E. ), Albsteric Moduktion of Amino Acid Receptors: Therapeutic Implications, pp. 31-46. Raven Press, N e w York. W. (1982). The distribution of [3H]kainic acid binding sites in rat CNS as determined by autoradiography. Rrain Res. 252, 91-100.
Continued 34 Figure 4. continued 35 Figure 4. continued Figure 4. continued 37 2. 01 Insular cortex Putamen "Number of cases = 6; age = 67 ± 3 years; postmortem delay = 15 ± 3 hr. All values expressed as mean pmol/mg protein ± SEM. 5 mM CaCl 2. 5 μΜ quisqualate. 5 μΜ quisqualate. 04* "Number of cases = 9; age = 64 ± 6 years; postmortem delay = 15 ± 3 hr. All values expressed as pmol/mg protein ± SEM. 5 mM CaCl 2 . 5 μΜ quisqualate. 5 μΜ quisqualate. e 62 nM [3H]kainate. ^Stratum lucidum of CA3.
A high level of heterogeneity was observed in QNB binding in the cortex, which was evident both within and across cortical regions (Figure 1). A distinct lamination was observed in all cortical regions. Layers 1 and 2 contained the highest density of label. In most cortical regions, a lighter layer 3 is followed by an increase in density over layer 4, a decrease over layer 5, and a slight increase over layer 6. Layer 5 often presents the lowest binding density within the cortex. The primary visual area (area 17) has a unique pattern of lamination: Dense labeling is seen over the outermost and innermost layers, and a band in the middle (corresponding to the visual stria) is considerably lighter (Figure 1).
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