By L. S. Evseenko, S. W. Gorkova, E. A. Minenkova, M. M. Fomina (auth.), K. Hellmann, T. A. Connors (eds.)
The overseas Society of Chemotherapy meets each years to check development in chemotherapy of infections and of malignant disorder. each one assembly will get higher to surround the extension of chemotherapy into new parts. In a few circumstances, exp~sion has been quick, for instance in cephalosporins, pen icillins and mixture chemotherapy of melanoma - in others sluggish, as within the box of parasitology. New difficulties of resistance and untoward results come up; relief of host toxicity with no lack of antitumour task through new ingredients occupies huge realization. the enhanced effects with melanoma chemotherapy, es pecially in leukaemias, are resulting in a better occurrence of serious an infection in sufferers so handled, pharmacokinetics of substances in general and diseased topics is rece1v1ng expanding consciousness in addition to similar difficulties of bioavailability and interactions among medicines. in the meantime the assault on a few of the significant bacterial infections, resembling gonorrhoea and tubercu losis, that have been one of the first infections to suppose the effect of chemotherapy, nonetheless stay significant global difficulties and at the moment are less than assault with new brokers and new equipment. From this vast box and the 1,000 papers learn on the Congress we've produced court cases which mirror the range and power of study during this very important box of drugs. It was once impossible to incorporate the entire papers offered on the Congress yet we now have tried to incorporate so much points of cur lease development in chemotherapy.
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JELLINGHAUS ET AL. If a long releasing time is a general property of Vincristine it is unlikely that Vincristine will be a suitable agent for synchronisation in vivo. Literature 1. : Cancer Res. 32: 2452-2458 (972) 2. : Cancer Res. 24: 1918-1925 (1964) 3. Krebsforsch. 79: 213-220 (1973) 4. Krebsforsch. in press (1975) 5. Wschr. 97: 1273/1282 (1972) 6. : Proc. 7th Int. Congr. Chemother. 2: 353-355 (1972) 7. Wschr. 100: 54-56 (1975) 8. : Bull. s,J. 1st Institute of Pathology,Semmelweis Medical University, Budapest, Ulloi ut 26, Hungary From the results of clinical and experimental tumour chemotherapy it seems that no single agent seems to be able to deal effectively with most of the human tumours and reasonable therapeutic results can only be reached by combinations of drugs.
To make the model easier to understand, we made idealised assumptions. We assumed that the cycle time remains constant even L 1210 ASCITES TUMOUR CELLS AND CRYPT EPITHELIA 10 20 33 30 hours Fig. 2 Theoretical model to calculate the mitotic and labelling indices at any time after Vincristine injection. (For details see text) under the influence of Vincristine, that the duration of mitosis after the release of the Vincristine bloc is not changed and that the cells have a constant frequency distribution along the cycle.
CycloiltlOsrhclLide DED + 5-FU D3D ... "elm DED ... VCR OBD+BLEC DBD+DilD I I I more than "dClitive core than edJltive audItive lese than nduttive less than additIve less than adctlhv~ + Flanning combined therapy. The! 1tperimentsl and Clinical Stud1",,,,. Cfll'ter. Cancer CheClotherspy Reports. Pert 2. '. l. pp. Figure 6 42 K. LAPIS ET AL. alkylates the components of the chromatin, differs from Bleomycin in its chemical activity, and the two drugs belong to two groups with different mechanisms of action.
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