By Dennis A. Wigle Ph.D., Igor Jurisica Ph.D. (auth.), Igor Jurisica PhD, Dennis A. Wigle MD, Bill Wong BSc, MBA (eds.)
Medical details technology calls for analytic instruments. this can be completed by way of constructing and assessing equipment and platforms for the purchase, processing, and interpretation of sufferer information, aided by way of clinical discovery. Cancer Informatics in Post-Genomic Era offers either the mandatory technique and functional info instruments.
Key demanding situations contain integrating examine and scientific care, sharing information, and constructing partnerships inside of and throughout sectors of sufferer prognosis and therapy.
Addressing vital scientific questions in melanoma study will reap the benefits of increasing computational biology.
The creation of genomic and proteomic applied sciences has ushered forth the period of real medication. The promise of those advances is correct "personalized drugs" the place therapy techniques will be separately adapted and strengthen to beginning intervention earlier than noticeable signs seem.
Series editor comments:
"Cancer informatics has develop into a severe portion of smooth investigations. a mixture of system's biology and the significance of knowledge units linked to melanoma learn require subtle applied sciences to control the large spectrum of collective wisdom. this article presents a finished overview of the sector awarded via leaders within the discipline."
Steven T. Rosen, M.D.
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Extra resources for Cancer Informatics in the Post Genomic Era: Toward Information-Based Medicine
The development of special techniques by microwave treatment to recover the antigenicity of formalin-denatured proteins has greatly enhanced the value of these materials for protein expression studies using the immunohistochemistry technique. The invention of tissue microarray (TMA) has further enhanced the value of paraffin tissue blocks in high throughput validation research on human tumors. In TMA, small (6-15 mm diameter) cores of formalin fixed and paraffin embedded tissue are arrayed into a single paraffin block.
Entry of tumor cells into the circulation is the critical first step in the metastatic cascade, and although it has been assayed in various ways (Liotta, Kleinerman et al. 1974; Butler 1975; Glaves 1986), it has not been observed directly. Novel approaches that rely on the ability to specifically “mark” the tumor cell are promising. For example, one can engineer tumor cells to express the green fluorescence protein for in vivo fluorescence imaging. In order to understand the metastatic pattern of NSCLC, Yang M et al.
For some cases, several tissue fragments from different areas of the tumor were harvested at a single time point to study gene expression heterogeneity within the tumor. Each sample was snap-frozen after harvesting, and stored in liquid nitrogen until analysis. Remarkably, similar gene expression profiles were obtained for the majority of samples regardless of the time that had elapsed between resection and freezing. It was found that the variations between multiple samplings were significantly greater than those of elapsed time between sampling/freezing (Figure 4).
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