By B. Terracini (auth.), P. A. Voûte, Ann Barrett, Jean Lemerle (eds.)

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In the interstitium of the testes, however, where the leukaemic cells are characteristically found, a pharmacological barrier has not been demonstrated [33], while in the CNS the blood-brain barrier (BBB) constitutes a physiological barrier formed by the endothelium of brain capillaries. The BBB prevents most of the antineoplastic agents from penetrating the CNS in therapeutic concentrations. This barrier, which is not uniformly intact in brain tumours, appears to function in at least some areas of the tumour [34].

Tabin, CJ, Bradley SM, Bargmann CJ, Weinberg RA, Papageorge AG, Scolnick EM, Dhar R, T ~·"Y DR, Chang EH (1982) Mechanisms of activation of a human oncogene. Nature 300: 143-149 16. Hagemeijer A, Smit EME, Bootsma D (1979) Improved identification of chromosomes of leukemic cells in methotrexate treated culture. Cytogenet Cell Genet 23: 208-212 17. Mitelman F (1988) Catalogue of chromosome aberrations in cancer, 3rd edn. Liss, New York 18. Schimke RT (1984) Gene amplification in cultured animal cells.

Cell 37: 1035-1042. 30. abl gene of the Philadelphia chromosome. Science 247: 824-830 31. van der Plas DC, Hermans ABC, Soekarman D, Smit EME, de Klein A, Smadja N, Alimena G, 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. Goudsmit R, Grosveld G, Hagemeijer A (1989) Cytogenetic and molecular analysis in Philadelphia negative CML. Blood 73: 10381044 Hermans A, Heisterkamp N, von Lindern M, van Baal S, Meijer D, van der Plas D, Wiedemann LM, Groffen J, Bootsma D, Grosveld G (1987) Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia.

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Cancer in Children: Clinical Management by B. Terracini (auth.), P. A. Voûte, Ann Barrett, Jean Lemerle
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