By Kenneth J. Craddock, Shirley Tam, Chang-Qi Zhu, Ming-Sound Tsao (auth.), Ulrich Pfeffer (eds.)

The blend of molecular biology, engineering and bioinformatics has revolutionized our knowing of melanoma revealing a decent correlation of the molecular features of the first tumor when it comes to gene expression, structural changes of the genome, epigenetics and mutations with its propensity to metastasize and to answer treatment. it isn't only one or a number of genes, it's the advanced alteration of the genome that determines melanoma improvement and development. destiny administration of melanoma sufferers will as a result depend on thorough molecular analyses of every unmarried case.

Through this ebook, scholars, researchers and oncologists will receive a complete photograph of what the 1st ten years of melanoma genomics have printed. specialists within the box describe, melanoma by way of melanoma, the development made and its implications for analysis, diagnosis and remedy of melanoma. The deep effect at the clinics and the problem for destiny translational learn turn into glaring.

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Nat Rev Cancer 7(10):778–790 ˜ res E, Shepherd FA, Crowley J, Van Houtte P, Postmus PE, Carney D, Chansky K, 7. ValliAR Shaikh Z, Goldstraw P (2009) The IASLC Lung Cancer Staging Project: proposals regarding the relevance of TNM in the pathologic staging of small cell lung cancer in the forthcoming (seventh) edition of the TNM classification for lung cancer. J Thorac Oncol 4(9):1049–1059 8. Govindan R, Page N, Morgensztern D, Read W, Tierney R, Vlahiotis A, Spitznagel EL, Piccirillo J (2006) Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database.

J Clin Oncol 23(25):5900–5909. 857 42. Kosaka T, Yatabe Y, Onozato R, Kuwano H, Mitsudomi T (2009) Prognostic implication of EGFR, KRAS, and TP53 gene mutations in a large cohort of Japanese patients with surgically treated lung adenocarcinoma. J Thorac Oncol 4(1):22–29. 0b013e3181914111 43. Mascaux C, Iannino N, Martin B, Paesmans M, Berghmans T, Dusart M, Haller A, Lothaire P, Meert AP, Noel S, Lafitte JJ, Sculier JP (2005) The role of RAS oncogene in survival of patients with lung cancer: a systematic review of the literature with meta-analysis.

Guo NL, Wan YW, Bose S, Denvir J, Kashon ML, Andrew ME (2011) A novel network model identified a 13-gene lung cancer prognostic signature. Int J Comput Biol Drug Des 4(1):19–39. 038655 [pii] 137.

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Cancer Genomics: Molecular Classification, Prognosis and by Kenneth J. Craddock, Shirley Tam, Chang-Qi Zhu, Ming-Sound
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