By Y. Shoenfeld (Editor), M.E. Gershwin (Editor)
Of the 2 disciplines in parallel improvement for 2 a long time, tumor immunology and transplantation immunology, the latter has thrived and has ended in the most serious discoveries in immunobiology. the previous maintains to thwart either scientists and clinicians alike. The aim of immunologists in modern-day study is to boost an easy and potent capacity to govern melanoma in vivo, probably encompassing numerous venues: settling on a phenotypic marker and using both energetic or passive immunization; contain using passive reagents sporting "warheads" to selectively spoil melanoma cells; or changing the elemental technique of telephone survival. this wonderful multidiscipline-authored quantity offers a subject matter which has no longer been good defined ahead of. The papers contain either uncomplicated and medical technological know-how and variety from subtle molecular biology to little greater than phenomenology (e.g. the elevated organization of melanoma in a few autoimmune ailments and elevated presentation of autoimmune phenomena in malignant condition). This, besides the fact that, is state of the art. This selection of subject matters should be of use not just to bench scientists, but in addition to clinicians who deal with sufferers. The publication represents development on the innovative of this self-discipline, and issues the best way to extra advancements within the "black field" of immunology.
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Additional info for Cancer and Autoimmunity (Autoanitbody Library)
Postgrad Med 1977;53:173-174. Pointud P, Prudat M, Peron JM. Acute leukemia after low dose methotrexate therapy in a patient with rheumatoid arthritis. J Rheumatol. 1993;20:12151216. Bendix G, Bjelle A, Holmberg E. Cancer morbidity in rheumatoid arthritis patients treated with Proresid or 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. 62. parenteral gold. Scand J Rheumatol 1995;24(2):7984. Clausen JE, Arndal JC, Gram L, Kudahl SB. Chronic lymphocytic leukemia after treatment with penicillamine [letter].
Since SLE is associated with abnormal growth of cells of the immune system, several researches have studies the expression of various oncogenes in patients with SLE. In vitro studies  have indicated that activation and proliferation of the B cells, from normal people and SLE patients with IgM antibodies, resulted in expression of c-myc proto-oncogene RNA. Boumpas et al.  found that in vitro activation of T and B cells from patients with SLE had significantly increased expression of c-myc, c-myb and c-raf RNA compared with normal cells.
Lymphomas occurred in patients with mild and severe form of RA. Nodal and extra-nodal cases of lymphomas were reported among patients of RA. Cases of lymphomas localized to the joints and presenting as monoarticular swelling have also been reported [34-35]. Several cases have indicated a link between NHL and treatment with DMARDs [31-38]. Whether lymphoma in patients with RA develops as a result of the disease state, or its treatment with cytotoxic agents, remains controversial. 2 years. No predominance of specific clinical or histological type was noted and none of the patients received cytotoxic drugs in that series .
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