By Roger Wallace

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Additional resources for Biological Interpretation of Dose from Accelerator-Produced Radiation

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If i t r e q u i r e d two ionizations t o produce the effect, then m o r e densely ionizing radiation would be m o r e likely to deposit two ionizations within the volume hit, and t h e r e f o r e m o r e densely ionizing radiations would be m o r e efficient at producing mutations. If, however, it r e q u i r e d only one ionization t o produce the effect, then m o r e densely ionizing radiation would not be m o r e efficient, and, a s a matter of fact, might be found to be l e s s efficient than s p a r s e l y ionizing radiations i n that they might deposit all of t h e i r e n e r g y within a single t a r g e t and so effectively waste ionizations o r dose.

1 2 F i g u r e 11 shows the radiosensitivity of lysozyme a s a function of the pH of the enzyme solution, saturated e i t h e r with oxygen o r with nitrogen, during the exposure. C o n t r a r y to what applies i n cellular radiobiology the p r e s e n t r e s u l t s show that the radiosensitivity i s g r e a t e r in nitrogen than i n oxygen a t m o s p h e r e , f o r x r a y s a s well a s for carbon ions. These r e s u l t s show that compared with nitrogen, oxygen a c t s a s a radioprotective compound o v e r the e n t i r e pH range studied, but the d e g r e e of this oxygen protection i s smaller f o r carbon ions than for x r a y s .

5 as a function of the average stopping power of the solution. 8 MeV/amu). 8 M e V k m u ) . Fig. 10. 42 Fig. 11. The radiosensitivity of lysozyme in N and in 02-saturated solutions of various pII for 150-kV x r a y s and 110-Me5 C 6 t ions. The radiosensitivity of lysozyme dried from solutions of various pH and irradiated in high vacuum with C 6 + ions i s shown for comparison. -. /. oI Fig. 12. 5 as a function of the concentration of glycerol in the solution. 43 100 microns ARGON NEON A A OXYGEN CARBON F i g .

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Biological Interpretation of Dose from Accelerator-Produced by Roger Wallace
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