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M. Simonis 100 -i 50 75 1Q0 ED 50 125 150 175 200 225 250 Dote (mg) Fig. 18. The relation between the response (the percentage of the individuals who have reacted at the given dose) and the dose of a xenobiotic. This is a cumulative representation of Fig. 17. The dose-response curve exhibits an asymmetrical character. When this curve is plotted on a log dose scale, a symmetrical curve is obtained (see Fig. 16). icodynamic phase are small. However, in the exposure phase and especially in the toxicokinetic phase the individual variations are much larger.
If the dosage of a carcinogen is low enough, the animal dies before the resulting cancer is manifested, but this does not mean that the dose of substance is noncarcinogenic. Irreversible, covalent binding results in "chemical sequestration" of the toxic agent in the organism (see Fig. 4) and implies that extraction from the tissues with hydrophilic or lipophilic solvents is not possible (Fig. 7). 3. Toxicity based on physical sequestration usually concerns accumulation of highly lipid-soluble, metabolically stable compounds in lipid-rich tissues.
And Scribner, J. " Springer-Verlag, Berlin and New York, 1973, p. ) 32 E. J . Ariens and A. M. Simonis nevertheless is considered undesirable b e c a u s e of the risks. It is a matter of chemical hygiene. This physical sequestration (see Fig. 4) implies the possibility of extracting the agents c o n c e r n e d from the tissues by means of suitable solvents. , polybrom- biphenyls, used for a variety of technical applications, and plasticizers, such as diethylhexylphthalate ( D E H P ) , reaching man via a migration bronchi kidney (al) liver bronchi kidney (a2) Fig.
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