By Linda A. Felton, James W. McGinity
This hugely praised e-book offers an in-depth research of actual and chemical houses and functions of aqueous-based polymeric coatings-covering covered dosage varieties, movie defects, and polymer characterization. New chapters on plastisizers and their purposes in pharmaceutical coatings, adhesion of polymeric motion pictures to sturdy substrates, and the impression of pigments on houses of the polymeric coating structures are integrated during this 3rd version. also, this identify offers new fabric on polymer interactions with medicines and excipients and actual getting older of polymeric motion pictures.
Read or Download Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms, 3rd Edition (Drugs and the Pharmaceutical Sciences) PDF
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Additional resources for Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms, 3rd Edition (Drugs and the Pharmaceutical Sciences)
Below the Tg, the polymer is rigid and glassy, with very limited polymer segment movement. Above the Tg, the polymer is in a soft rubbery state, with significant segmental mobility of the polymer chains. If the polymer Tg is Figure 16 Effect of sufficient/insufficient plasticizer content on coating morphology. Abbreviation: DBS, dibutyl sebacate. 18 Carlin et al. 8 at 170°C Insoluble NA Nonvolatile Negligible Abbreviations: DBS, dibutyl sebacate; DEP, diethyl phthalate; TEC, triethyl citrate; TBC, tributyl citrate; ATBC, acetyl tributyl citrate.
Additional studies of morphological changes in latex films. J Macromol Sci Phys 1972; B6:671–694. Hahn K, Ley G, Schuller H, et al. On particle coalescence in latex films. J Colloid Polym Sci 1986; 264:1092–1096. Hahn K, Ley G, Oberthür R. On particle coalescence in latex films (II). J Colloid Polym Sci 1988; 266(7):631–639. Sperling LH, Klein A, Yoo JN, et al. The utilization of SANS to solve polymer latex structural problems: basic science and engineering. Polym Adv Technol 1990; 1(3–4):263–273.
Abbreviation: TEC, triethyl citrate. Source: From Ref. 30. which may be too much for some poorly permeable drugs, requiring precision coating using very low loadings. To increase permeability in such cases, poreforming excipients may be added to the coating formulation. Typically, curing for one to two hours at 60°C will be sufficient, as shown in Figure 14. Curing can be carried out by oven heating or in situ heating in a fluidbed coater using increased fluidization to avoid pellet agglomeration.
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