By Margot Mayer-Pröschel (auth.), Prof. Dr. W. Poewe, Dr. G. Ransmayr (eds.)

The e-book comprises unique articles and experiences provided on the sixth overseas wintry weather convention on Neurodegeneration, held from November 20–23, 1997 in Kitzbuhel/Austria. the purpose of this convention used to be to offer and talk about fresh info at the interface among neuroimmunology and neurodegeneration, specifically susceptibility to autoimmune and neurodegenerative tactics, neuroprotection and restorative remedy ideas. those concerns have been mentioned within the mild of contemporary advancements in a number of sclerosis, Parkinson’s ailment, amyotrophic lateral sclerosis, Huntington’s sickness and multisystem atrophy. The articles spotlight themes, that are really attention-grabbing for the clinician and the neuroscientist. the various neuroprotective recommendations have already been constructed or are at this time clinically investigated. The neuroprotective position of deep mind stimulation, antiglutamatergic treatment and apomorphine could be proven in scientific stories within the close to destiny. this is often additionally the case for destiny healing ways to recovery of the broken worried method, reminiscent of somatic gene treatment, implantation of genetically changed cell-lines and medically managed and directed improvement of embryonic cells. The convention highlighted the function of the glia, which turns out to play a key function, either in usually as neuroimmunological and neurodegenerative problems labeled ailments, as indicated above. the themes mentioned within the publication are major for fresh advancements in medical neurology and neuroscience, as proven within the present literature and at overseas congresses.

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The results show that the development of motor complications was significantly less frequent in patients treated with cabergoline than in levodopa recipients (22 % vs. 34 %) and that the relative risk of developing motor complication during treatment with cabergoline was more than 50% lower than with levodopa. This trials also show that 35% of the patients treated with cabergoline did not require additionallevodopatherapy all along the follow-up, remaining on agonist monotherapy at the time of analysis.

Four of them are relatively "old" ones: bromocriptine, lisuride, pergolide, piribedil. The three others are "newer" drugs, which have been put on the market within the last twelve months: cabergoline, pramipexole and ropinirole. All these dopamine agonists share the property to bind to the D2-like family of dopamine receptors. However, all of them have specific characteristics, which provide some differences from one drug to the other. , 1993; Uitti and Ahlskog, 1996). These differences are often put forward for marketing purposes, to try to establish that these compounds are not "metoo" drugs.

These differences are often put forward for marketing purposes, to try to establish that these compounds are not "metoo" drugs. However, the results of the controlled comparative clinical trials, when available, are far less demonstrative and do not often convince that any agonist is indeed truely superior to the others. Which agonist to prefer, and when to use it to treat optimally our patients with Parkinson's disease are thus two distinct questions which both remain unslolved at the present time, because we still lack, in 1998, objective, reliable and convincing demonstrative comparative data.

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Advances in Research on Neurodegeneration: Volume 6 by Margot Mayer-Pröschel (auth.), Prof. Dr. W. Poewe, Dr. G.
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