By Anderson T. Wang, Peter J. McHugh (auth.), Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali (eds.)

​A finished assessment of the new advancements in DNA fix examine that experience capability for translational functions. The booklet explains intimately a few of the organic mechanisms during which melanoma cells can avert anticancer remedy and boundaries its usefulness in sufferers. in addition they evaluate the influence of such novel inhibitors of DNA fix mechanisms as methylguanine-DNA-methyltransferase. additionally tested are inhibitors of different DNA fix enzymes reminiscent of PARP and DNA-PK. The booklet captures-for either melanoma researchers and oncologists facing hallmark "relapse" or "drug resistance" phenomena on a regular basis-the many intriguing new makes use of of DNA fix inhibitors, both by myself or together with anticancer therapies.​

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O’Driscoll M, Jeggo PA (2006) The role of double-strand break repair—insights from human genetics. Nat Rev Genet 7(1):45–54 7. Begg AC, Stewart FA, Vens C (2011) Strategies to improve radiotherapy with targeted drugs. Nat Rev Cancer 11(4):239–253 8. Helleday T, Petermann E, Lundin C et al (2008) DNA repair pathways as targets for cancer therapy. Nat Rev Cancer 8(3):193–204 9. Guzi TJ, Paruch K, Dwyer MP et al (2011) Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening.

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Advances in DNA Repair in Cancer Therapy by Anderson T. Wang, Peter J. McHugh (auth.), Lawrence Panasci,
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